Expression and Significance of Epstein-Barr Virus-Latent Membrane Protein 1 in Acquired Immune Deficiency Syndrome-Related Diffuse Large B-Cell Lymphoma

We aimed to investigate the expression and significance of Epstein-Barr virus-latent membrane protein 1 in human immunodeficiency virus-related diffuse large B-cell lymphomas. 22 cases lymphomas samples were collected. The control group consisted 7 non-human lymphomas, 6 virus-reactive hyperplasia virus. was detected by immunohistochemistry analyzed combination with clinicopathology characteristics. total positive rate 77.3 % 71.4 Most related cells showed nuclear staining pattern 82.4 60 There no significant difference between benign lesion. non-germinal center B cell significantly higher than that germinal However, had correlation sex, age, location tumor clinical stage (p>0.05). mainly located overexpressed suggesting overexpression involved tumourogenesis correlated immunophenotype As prognosis different subgroups, may be potential marker for